Service Introduction:

　ADME is the abbreviation of "Absorption, Distribution, Metabolism and Excretion" of drugs, which represents the process of the body's treatment of drugs after the drugs enter the body. The four attributes of a drug determine the concentration, tissue distribution and metabolic pathway of a drug in the body, which are useful for predicting the bioavailability and biological activity of the drug (that is, whether a drug can reach its target point and produce corresponding therapeutic effects) has important reference value. Therefore, understanding the ADME properties of compounds is of great significance to the drug development process.
　Drug development is a high-risk, high-investment, but also a high-reward process. In this process, the sooner the ADME properties of the drug are evaluated and optimized, the timelier the compounds with poor ADME properties can be eliminated, thereby reducing unnecessary investment and waste of resources in the later period. KSI can provide you with ADME testing services, including high-throughput ADME screening, in vitro drug metabolism testing, drug permeability and transport experiments, etc.

service items:

Plasma kinetic studies
Organizational Distribution Research
Metabolism Research

In vivo pharmacokinetics

Animal strain
Mouse, rat, hamster, guinea pig, rabbit, dog, macaques
Route of administration
Intravenous injection, oral (gavage), subcutaneous injection, intraperitoneal injection, intramuscular injection, intravenous infusion, subcutaneous infusion, nasal and lateral ventricle injection, rectal administration, skin administration, etc.
Sample Collection
Blood collection from jugular vein, dorsal foot vein and femoral vein, orbital blood collection, submandibular vein blood collection, cerebrospinal fluid collection, lymphatic fluid collection and all tissue collection
Surgical Service
Hepatic portal vein cannula
Intestinal lymphatic catheterization
Bile duct intubation (rat, dog, macaques)
Duodenal intubation anticipation
End-point cerebrospinal fluid collection in mice and in vivo cerebrospinal fluid collection (rats, dogs, macaques)
Biological intermediate
Blood, plasma, urine, tissue, cerebrospinal fluid, brain, sciatic nerve, Dorsal root ganglion, lymph nodes, microscopic and all other tissues