ADME Research

       Commonly sampled matrices used in in vivo pharmacokinetic assays include whole blood, plasma, serum, brain tissue, cerebrospinal fluid, bile, urine, feces, liver tissue, gastrointestinal tract tissue, and other specific tissues and tissue fluids. If the concentration of a drug in a specific tissue is particularly important, plasma samples can be collected in parallel with the collection of that tissue or tissue fluids at different time points, thus obtaining the ratio of tissue drug concentration to plasma concentration (e.g., brain tissue can be collected to assess the brain/plasma drug concentration ratio), and the collection of bile, urine, and fecal excretions over a certain period of time can be used to obtain the major metabolism of a drug in the body.

       Through these methods, the absorption, distribution, metabolism, and excretion processes of drugs in the body can be comprehensively evaluated, providing scientific basis for drug development and application.

Our services

experiment	describe	Species and genus	result
Organizational distribution	Collect plasma and heart within the set time, Liver, spleen, lungs, kidneys, small intestine, colon, Testicles, ovaries, brain, muscles, skin, Thymus and other tissue samples. Quantitative analysis using LC/MS/MS method	mice Rat dog other	Drug concentrations and their ratios in tissues and plasma report
Cerebrospinal fluid permeability	IV/PO/IP and other routes of administration Collect plasma and cerebrospinal fluid samples within the set time LC-MS/MS for quantitative analysis	Rat dog other	Cerebrospinal fluid drug concentration Report on cerebrospinal fluid plasma drug concentration ratio

      After drug administration, absorption, distribution, metabolism, and excretion processes occur in the body, known as ADME. Suzhou Kaisai Company uses animals to study the mechanism of ADME in vivo.

experiment	describe	Species and genus	result
excretion	Research on complete animal feces and urine excretion Study on bile excretion in animals with bile duct catheterization Collect fecal, urine, or bile samples at set intervals within a specified time frame LC-MS/MS for quantitative analysis	Rat other	Report on the recovery rate of substances in feces, urine, and bile