Key models for drug development in sarcopenia
Sarcopenia, a syndrome caused by persistent loss of skeletal muscle mass, strength and function. Skeletal muscle is the driving force of the body's locomotor system, and aging and atrophy of muscle is a major sign of aging in the human body, and is highly susceptible to problems such as bone fractures as well as joint damage. Elderly people with sarcopenia have difficulty standing, have a slow gait, and are prone to falls and fractures. Sarcopenia also affects organ function and can lead to heart and lung failure and even death.We have established a stable model of sarcopenia that is suitable for preclinical sarcopenia drug research and new drug evaluation.
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Disease name | Model name | Animal species |
Sarcopenia | Dexamethasone induced sarcopenia model | mouse, rat |
Myopenia model caused by type I diabetes | rat | |
Sarcopenia caused by weight loss with semaglutide | mouse | |
A model of sarcopenia caused by high-fat diet | mouse, dog |
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Dexamethasone induced mouse sarcopenia model
