Key Models for Atherosclerosis Drug Development

Atherosclerosis, commonly known as “hard blood vessels”, is mainly caused by endothelial lipid accumulation, fibrous tissue proliferation and calcium deposits, with no obvious symptoms in the early stage, and large and medium-sized arteries (such as coronary arteries, carotid arteries, cerebral arteries, renal arteries and so on) are more likely to be affected by the lesions. In general, the prognosis of atherosclerosis is based on the location and extent of the lesion, the rate of development of stenosis, the damage to the affected organs, and the presence or absence of complications, and the prognosis of atherosclerosis is worse when the lesion involves important organs such as the heart, the brain, and the kidneys.
　　We have established a stable model of diet-induced atherosclerosis, which is suitable for preclinical studies of drugs for atherosclerosis treatment and evaluation of new drugs.
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Model classification	Model Name	Animal species
Atherosclerosis	Apoe-/- Mouse + Western Diet-Induced Atherosclerosis Model	Mice
	Atherosclerosis model induced by high-fat and high-cholesterol feed in rabbits and nonhuman primates	Rabbit