Key models for drug development in acute kidney injury
Acute kidney injury (AKI) is a group of clinical syndromes characterized by a sudden (within 1-7 d) and sustained (>24 h) decline in renal function, defined as a rise in serum creatinine (SCr) of at least 0.5 mg/dl 1 , manifested by azotemia, water-electrolyte and acid-base balance, and generalized systemic symptoms, which may be associated with oliguria (<400 ml/24h or 17 ml/h) or anuria (<100 ml/24h). /24h).We have established stable multiple models of acute kidney injury, which are suitable for preclinical studies of drugs with acute kidney injury and evaluation of new drugs.
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Model classification | Model Name | Animal species |
Acute kidney injury | Ischemia-reperfusion-induced acute kidney injury model | Mice，rats |
Cisplatin-induced acute kidney injury model | Mice，rats | |
Glycerol-induced acute renal failure model | Rats |
Case sharing
Acute kidney injury model
UUO induced renal fibrosis model
