In vitro drug distribution and protein binding studies

        The distribution of drugs in different tissues depends on various factors, including physiological factors such as tissue blood flow rate and physiological barriers, as well as the characteristics of the drug itself, such as plasma protein binding rate, tissue affinity, and lipid solubility.

        The plasma protein binding rate of a drug is an important parameter for characterizing the drug distribution process.In the absence of active transport, only the unbound free drug can cross the biofilm and enter the corresponding tissues to exert pharmacological effects or to be metabolized and excreted. When equilibrium is reached during the distribution process, the bound and free drugs in plasma and tissues are in a dynamic equilibrium state. Plasma protein binding rate is of great importance in the construction of pharmacokinetic (PK) and pharmacodynamic (PD) correlation models, prediction of drug interactions, evaluation of drug toxicity, prediction of pharmacokinetic parameters in humans and prediction of dosage administration.

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