Key model for the development of disseminated intravascular coagulation drugs
Disseminated Intravascular Coagulation (DIC) is a clinical syndrome characterized by bleeding and microcirculatory failure due to damage to the microvascular system by pathogenic factors on the basis of many diseases, resulting in coagulation activation, systemic microvascular thrombosis, massive depletion of coagulation factors and secondary hyperfibrinolysis. Disseminated intravascular coagulation is not an independent disease, but an intermediate link in the complex pathological process of many diseases. According to the speed of occurrence of disseminated intravascular coagulation, it is divided into acute, subacute, and chronic types; according to the compensation of disseminated intravascular coagulation, it can be divided into loss of compensation, compensation, and overcompensation.We have established a stable lipopolysaccharide (LPS)-induced diffuse intravascular coagulation model, which is suitable for the study of drugs with preclinical diffuse intravascular coagulation and the evaluation of new drugs.
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Model classification | Model Name | Animal species |
Disseminated intravascular coagulation | Model of lipopolysaccharide (LPS)-induced diffuse intravascular coagulation | Rats |