Key Model for Drug Development of Pericarditis
Pericarditis refers to acute inflammatory reaction and exudation of the pericardium due to bacterial, viral, autoimmune, physical and chemical factors, as well as chronic lesions such as pericardial adhesions, thickening, constriction and calcification. Clinically, there are mainly acute pericarditis and chronic constrictive pericarditis. Patients have fever, night sweats, cough, sore throat or vomiting, diarrhea and other symptoms. Acute pericardial tamponade symptoms can occur when the pericardium leaks a large amount of fluid. Patients have chest pain, dyspnea, cyanosis, pallor, and even shock. Symptoms such as ascites and hepatomegaly may also be present.We have established a stable model of yeast zymosan A (ZIA)-induced pericarditis, which is suitable for the study of drugs for preclinical pericarditis and the evaluation of new drugs.
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Model classification | Model Name | Animal species |
Pericarditis | Model of yeast zymosan A (ZIA)-induced pericarditis | Rats |