Key model of drug development for complications of diabetes
Diabetic complications are various complications that may occur after having diabetes for a long period of time, including cardiovascular disease, neuropathy, eye disease, kidney disease and so on. Diabetic patients can damage various tissues and organs due to long-term instability of blood sugar, leading to complications. Therefore, prevention and early treatment of diabetic complications are very important.We have established stable models of diabetic complications such as kidney, skin, and foot, which are suitable for the research of drugs for preclinical diabetic complications and the evaluation of new drugs.
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Model classification | Model Name | Animal species |
Complications of diabetes | Model of type II diabetic nephropathy induced by high-fat diet + streptozotocin (STZ) | Mice |
db/db mouse type II diabetic nephropathy model | Mice | |
Streptozotocin (STZ)-induced skin defect/scald model in type I diabetes mellitus | Rat | |
Streptozotocin (STZ)-induced foot ulcer model in type I diabetes mellitus | Rat | |
Streptozotocin (STZ)-induced peripheral vasculopathy model of type I diabetes mellitus | Rat | |
Heart Failure Model with Reduced Ejection Fraction Induced by db/db Mice + High-Fat, High-Cholesterol Feeding |