Key Model for Drug Development in Acute Liver Injury Model
Acute liver injury is mostly secondary to drug-induced hepatitis or hemorrhagic shock after trauma, resulting in injury secondary to insufficient blood supply and perfusion to the liver, and the patient will also have obvious pain in the liver area, as well as abdominal distension and jaundice, which will be manifested as an increase in aminotransferases and bilirubin. Acute phase should be treated systematically, otherwise liver insufficiency or even liver failure may occur, and in severe cases, liver necrosis may occur, which is life-threatening.We have established a stable carbon tetrachloride-induced acute liver injury model and an acetaminophen (APAP)-induced acute liver injury model, which are suitable for the study of drugs for preclinical NASH and the evaluation of new drugs.
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Model classification | Model Name | Animal species |
Acute liver injury | Carbon tetrachloride-induced acute liver injury model | Mice，rats，non-human primates |
Acetaminophen (APAP)-induced acute liver injury model | Mice |
Case sharing
Mice acute liver injury model
CCl4 induced mouse chronic liver fibrosis model
CCl4 induced rat chronic liver cirrhosis model
CCl4 induced NHP liver fibrosis model
