Key Model for Drug Development of Bronchiectasis
Bronchiectasis is caused by chronic suppurative inflammation and fibrosis of the bronchial tubes and their surrounding lung tissues, which destroys the muscular and elastic tissues of the bronchial walls, leading to deformation and persistent dilatation of the bronchial tubes. Typical symptoms include chronic cough, coughing up large amounts of purulent sputum and recurrent hemoptysis. When bronchiectasis is complicated by compensated or obstructive emphysema, patients may have dyspnea, shortness of breath or cyanosis, and in the advanced stage, they may show signs of pulmonary heart disease and cardiopulmonary failure.We have established a stable model of bronchiectasis, which is suitable for the study of drugs with preclinical bronchiectasis and the evaluation of new drugs.
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Model classification | Model Name | Animal species |
Bronchiectasis | Model of Pseudomonas aeruginosa-induced bronchodilatation | Mice |
Model of COPD combined with bronchiectasis |