In vivo PK study
In in vivo pharmacokinetic (PK) experiments, the modes of administration include, but are not limited to intravenous, oral, administration, intraperitoneal injection,intramuscular injection, subcutaneous injection, ventricular administration, intrathecal injection, nasal administration, and tracheal administration. The sampling time point can be set at 24 hours or more according to the characteristics of the compound and the specific requirements of the project, to ensure a comprehensive evaluation of the dynamic changes of the drug in the body.
Our services
experiment | describe | Species and genus | result |
Conventional single dose pharmacokinetics | Single dose administration for each route of administration; Collect 8-10 sampling time points before and after administration; Quantitative analysis using LC/MS/MS method; WinNolin8.2 software calculates PK parameters; Calculate the absolute bioavailability after extravascular administration. | Mouse, rat, rabbit, dog, monkey
| Medication time curve graph Basic PK parameters Bioavailability research report |
Multi dose pharmacokinetics | Single dose administration for each route of administration; Collect 8-10 sampling time points before and after administration; Quantitative analysis using LC/MS/MS method; WinNolin8.2 software calculates PK parameters; Calculate the absolute bioavailability after extravascular administration. | Mouse, rat, rabbit, dog, monkey | Medication time curve graph Basic PK parameters PK linear judgment Bioavailability research report |
Comparative pharmacokinetics | Test formulation and reference formulation; Collect 8-10 sampling time points before and after administration; Quantitative analysis using LC/MS/MS method; WinNolin8.2 software calculates PK parameters; Calculate the absolute bioavailability after extravascular administration. | Mouse, rat, rabbit, dog, monkey | Medication time curve graph Basic PK parameters Significant difference judgment Bioavailability research report |