Key models for cough medicine development
Cough is a common respiratory symptom caused by inflammation, foreign body, physical or chemical irritation of the trachea, bronchial mucosa or pleura, which is manifested first by the closure of the vocal folds, contraction of the respiratory muscles, and an increase in the intrapulmonary pressure, followed by the opening of the vocal folds, and the ejection of air from the lungs, usually accompanied by sound. Coughing has a protective effect in removing foreign bodies and secretions from the respiratory tract. However, if the cough does not stop and turns from acute to chronic, it often causes great pain to the patient, such as chest tightness, itchy throat and wheezing. Cough may be accompanied by coughing up sputum.We have established a stable citric acid + histamine-induced cough model in guinea pigs, which is suitable for the study of drugs for preclinical cough and the evaluation of new drugs.
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Model classification | Model Name | Animal species |
Cough | Citric acid + histamine-induced cough model in guinea pigs | Hamsters |