Key models for pain drug development
Pain disorders are categorized into neurological and pathological classifications, and pain symptoms are classified into transient, acute and chronic pain.We have established a stable variety of pain models that are suitable for research and new drug evaluation of drugs for preclinical pain.
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Model classification | Model Name | Animal species | |
Pain disorder | Inflammatory pain model | Model of formalin-induced inflammatory pain | Mice |
Model of inflammatory pain induced by complete Freund's adjuvant | Rats | ||
Model of induced inflammatory pain with keratan gum | Rats | ||
Capsaicin induced inflammatory pain |
| ||
Joint Pain Model | Sodium iodoacetate (MIA) induced osteoarthritis pain model | Rats | |
Meniscectomy + anterior cruciate ligament disarticulation (DMM+ACLT) induced osteoarthritis pain model | Rats | ||
Meniscectomy (DMM) induced osteoarthritis pain model | Rats | ||
Anterior cruciate ligament disarticulation (ACLT)-induced osteoarthritis pain model | Rats | ||
Model of meniscal detachment (MMT)-induced osteoarthritis pain | Rats | ||
Uric acid induced ankle pain model |
| ||
Incisional pain model | Surgical incision pain model | Mice，rats，dogs，pigs | |
Nerve Pain Model | Model of sciatic nerve chronic constriction injury (CCI)-induced pain | Mice，rats | |
Tumor pain model |
| Mice |
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