Key models for drug development in systemic sclerosis
Systemic sclerosis (SSc), also known as scleroderma, is a systemic autoimmune disease characterized by limited or diffuse skin thickening and fibrosis. The lesions are characterized by cutaneous fibroplasia and vascular onion skin-like changes, which eventually lead to skin sclerosis and vascular ischemia.We have established a stable model of bleomycin (BLM)-induced systemic sclerosis, which is suitable for preclinical systemic sclerosis drug research and new drug evaluation.
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Disease name | Model name | Animal species |
Systemic sclerosis | Model of systemic sclerosis induced by bleomycin (BLM) in the skin | mouse，rat |