Key Model for Drug Development of Huntington's Disease
Huntington's chorea (HD) is a rare autosomal dominant inherited neurodegenerative disease. The disease-causing gene, also known as the HTT gene, is located in the upper portion of chromosome 4, and its metabolite, Huntington's protein, is found in patients with Huntington's disease. Huntington's disease patients have many repetitions of the abnormal Huntington's protein, glutamine, which tends to adhere and aggregate, ultimately leading to the death of nerve cells.The main clinical symptoms of Huntington's chorea usually include three main categories: movement disorders, cognitive disorders, and psychiatric disorders. Movement disorders are characterized by choreiform movements, which can be accompanied by depression and impulse control disorders, and can eventually lead to dementia-like manifestations.
We have established a stable quinolinic acid-induced Huntington's chorea model, which is suitable for the study of preclinical Huntington's chorea drugs and the evaluation of new drugs.
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Model classification | Model Name | Animal species |
Huntington's disease | Quinolinic acid-induced model of Huntington's chorea | Non-human primates |