Key model of drug development for complications of diabetes

　　Diabetic complications are various complications that may occur after having diabetes for a long period of time, including cardiovascular disease, neuropathy, eye disease, kidney disease and so on. Diabetic patients can damage various tissues and organs due to long-term instability of blood sugar, leading to complications. Therefore, prevention and early treatment of diabetic complications are very important.
　　We have established stable models of diabetic complications such as kidney, skin, and foot, which are suitable for the research of drugs for preclinical diabetic complications and the evaluation of new drugs.
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Disease name	Model name	Animal species
Complications of diabetes	High-fat diet + streptozotocin (STZ)-induced  type II diabetic nephropathy model	mouse
	db/db mouse type II diabetic nephropathy model	mouse
	Streptozotocin (STZ)-induced peripheral vasculopathy model of type I diabetes mellitus	rat
	ZDF rat model of diabetic nephropathy	rat
	ZDF+HFD rat model of diabetic nephropathy	rat
	Streptozotocin (STZ)-induced cataract model of type I diabetes mellitus	rat

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