Key Models for NASH Drug Development
Non-alcoholic steatohepatitis (NASH), also known as metabolic steatohepatitis, is a clinical syndrome with pathologic changes similar to those of alcoholic hepatitis but without a history of excessive alcohol consumption, and is more common in middle-aged, especially overweight and obese individuals. NASH is closely related to metabolic disorders such as obesity, insulin resistance, type 2 diabetes, hyperlipidemia, etc. It is mainly characterized by hepatocellular vesicular steatosis with hepatocellular injury and inflammation, and in severe cases, it may develop into cirrhosis, for which there is no specific treatment.We have established stable multiple NASH models, which are suitable for preclinical NASH drug research and new drug evaluation.
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Disease name | Model name | Animal species |
NASH | DIO mouse NASH model | mouse |
Ob/ob mice+high-fat diet induced NASH model | mouse | |
NASH model induced by ob/ob mice and high-fat and high cholesterol diet | mouse | |
Db/db mice+MCD feed induced NASH model | mouse | |
NASH model induced by dbdb+high-fat and high cholesterol feed | mouse | |
NASH model induced by high-fat and high cholesterol feed | mouse，rat，hamster， rabbit，non-human primates | |
CDAA feed induced NASH model | mouse | |
NASH model induced by high-fat, high cholesterol, and high fructose feed | mouse | |
NAFLD model induced by low-fat and high fructose feed | rat | |
NASH model induced by high-fat diet and 30% fructose water | mouse | |
NASH model induced by high-fat diet and carbon tetrachloride | mouse | |
| NASH model induced by diethylnitrosamine (DEN)+ high-fat and high cholesterol feed | rat | |
NASH model induced by high-fat diet and streptozotocin (STZ) | mouse，rat | |
| NASH model induced by diethylnitrosamine (DEN)+ streptozotocin (STZ)+high-fat and high cholesterol feed | mouse |