Key models for drug development in acute lung injury

　　Acute lung injury (ALI) is an acute hypoxic respiratory insufficiency caused by damage to alveolar epithelial cells and capillary endothelial cells due to various direct and indirect injury-causing factors, resulting in diffuse interstitial and alveolar edema.
　　We developed a stable lipopolysaccharide (LPS)-induced acute lung injury model and a bleomycin (BLM)-induced acute lung injury model, which are suitable for the study of drugs with preclinical acute lung injury and the evaluation of new drugs. 
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