Key models for hypertension drug development
Hypertension (also known as elevated blood pressure), is a phenomenon in which blood flows at a consistently higher-than-normal pressure level against the walls of blood vessels. For patients with hypertension, lifestyle improvement and medication are the most common forms of treatment. The basic principles of drug therapy include prioritizing the use of long-acting antihypertensive drugs, controlling blood pressure over a 24-hour period, and adjusting drugs and dosages as needed. If a hypertensive patient's blood pressure remains uncontrolled for a long period of time, it may lead to more serious complications and may even result in fatal outcomes such as stroke and cerebral infarction.We have developed a variety of hypertension models that are suitable for preclinical research and new drug evaluation of drugs used to treat hypertension.
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Disease name | Model name | Animal species |
hypertension | Acetic deoxycorticosterone (DOCA)+high salt induced hypertension model | rat |
Dahl salt sensitive rats+high salt induced hypertension model | rat | |
Hypertension model induced by renal artery constriction | rat, dog, non-human primates | |
Hypertension model induced by abdominal aortic constriction | rats, rabbit, dog, non-human primates | |
SHR spontaneous hypertension model in rats | rat | |
A high-fat diet induced obesity induced hypertension model in dogs | mouse, dog | |
L-NAME induced hypertension model | rat |
Case sharing
DOCA+Salt Induced Hypertension Model
Renal Stenosis Induced Systemic Hypertension
Canine renal artery stenosis induced hypertension model
