About uterine fibroids
Its incidence rate increases with age. About 20% -50% of women of childbearing age are affected by it. Some patients suffer from anemia, infertility or poor quality of life due to serious symptoms.
Targeted hormone pathway:
1.GnRH antagonists (such as Relugolix): rapidly reduce estrogen levels, combined with hormone replacement therapy (HRT) to reduce side effects.2.Selective Progesterone Receptor Modulators (SPRMs): New generation drugs such as Vilaprsan reduce the risk of liver toxicity while reducing the volume of fibroids.
Non hormonal targets:1.TGF - β pathway inhibitor: Targeted regulation of proliferation and fibrosis of myomas.
2.Epigenetic regulators: such as histone deacetylase (HDAC) inhibitors, intervene in the expression of fibroid related genes.3.Gene therapy: RNA interference technology targeting driver genes such as MED12 is still in the preclinical research stage.
Multiple Phase II/III clinical trials have focused on combination therapies (such as Relugolix+estrogen/progesterone) and novel SPRMs, some of which have shown potential for long-term control of fibroid growth.
KCI Uterine Fibroids Pharmacology Platform
Compared to commonly used models such as mice and rats, Guinea Pig exhibits the following advantages in uterine fibroid research:The incidence of spontaneous uterine fibroids is relatively high: elderly female guinea pigs are prone to spontaneous formation of fibroids due to changes in hormone levels, which is closer to the natural course of human disease.
Hormone sensitivity: The physiological response of guinea pig uterus to estrogen/progesterone is similar to that of humans, and is suitable for evaluating the efficacy of hormone drugs.High matching degree of pathological features:
1.The histological structure of fibroids is consistent with that of humans (smooth muscle cell proliferation, extracellular matrix deposition);
2.Accompanied by similar hemodynamic changes (such as thickening of uterine arteries).
3.Pharmacokinetic characteristics: The drug metabolism enzyme spectrum of guinea pigs is closer to that of humans, which can improve the accuracy of drug toxicity prediction.KCI has established a mature guinea pig uterine fibroid model, which can be applied in fields such as drug screening, mechanism research, and combination therapy evaluation.
Experimental animal: Guinea pig, female
Model establishment:
Weight changes
Observation of the appearance of guinea pig uterus
organ index
Pathological changes in uterine horn
Pathological changes in the endometrium of the uterine horn
Pathological changes in the uterine horn muscle layer
