Key models for the development of hyperthyroidism drugs

Hyperthyroidism, or hyperthyroidism for short, is a clinical syndrome caused by thyrotoxicosis due to excessive production of thyroid hormone by the thyroid gland itself, resulting in accelerated metabolic activity in the body, increased excitability and hypermetabolism of the nervous, circulatory, digestive and other systems, and is often characterized by the main clinical manifestations of polyphagia, emaciation, palpitations, sweating and so on.The treatment methods for hyperthyroidism mainly include anti thyroid hormone drug (ATD) therapy, 131I therapy, and thyroidectomy therapy. Drug therapy usually uses antithyroid drugs (ATD), mainly by inhibiting the synthesis of thyroid hormones; Iodine 131 treatment destroys thyroid cells and lowers thyroid hormone levels; Surgical treatment involves removing the thyroid gland through surgery to reduce thyroid hormone levels. The treatment options for patients vary depending on factors such as differences in their condition, complications, age, gender, pregnancy status, and personal choices.
　　We have established a stable hyperthyroidism model suitable for preclinical drug research and new drug evaluation.
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