Key Model for SHPT Drug Development

Secondary hyperparathyroidism (SHPT, or secondary hyperparathyroidism) is a chronic compensatory clinical condition in which the parathyroid glands are chronically stimulated by low blood calcium, low blood magnesium, or high blood phosphorus and secrete excessive amounts of PTH in order to raise blood calcium, blood magnesium, and lower blood phosphorus in the presence of chronic renal insufficiency, intestinal malabsorption syndrome, Fanconi's syndrome, and renal tubular acidosis, vitamin D deficiency or resistance, as well as in the presence of pregnancy and lactation. Phosphorus, a chronic compensatory clinical manifestation of prolonged parathyroid hyperplasia eventually leading to the formation of functionally autonomous adenomas.
　　 We have established a stable SHPT model suitable for preclinical drug studies and new drug evaluation.
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