Evaluate Key Aspects of Cardiac Failure
Heart failure (HF) is a disease caused by a malfunction of the heart's pumping function, resulting in the heart's inability to meet the basic metabolic needs of the entire body. Frequent triggers include myocardial infarction, cardiomyopathy, and myocarditis. In acute heart failure, or acute exacerbation of chronic heart failure, patients may experience acute pulmonary edema, shock, syncope or even cardiac arrest, which can be life-threatening.We have established a stable model of heart failure caused by different triggers, which is suitable for preclinical research and new drug evaluation of drugs for the treatment of heart failure.
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Disease name | Model name | Animal species |
heart failure | Heart Failure Model Induced by Myocardial Infarction | mice, rats, rabbits, dogs, pigs, non-human primates |
Heart failure model induced by ascending aortic constriction | mouse | |
Heart failure model induced by aortic arch constriction | mouse, rat | |
Hypertension and heart failure model induced by abdominal aortic constriction | rats, rabbits, dogs, non-human primates | |
Heart failure model induced by pulmonary aortic constriction | rat | |
Acetic deoxycorticosterone (DOCA)+high salt induced hypertension induced heart failure model | rat | |
Dahl salt sensitive rats+high salt induced hypertension induced heart failure model | rat | |
Renal artery stenosis induced hypertensive heart failure model | rats, dogs, non-human primates | |
High fat diet induced heart failure model | mouse, hamster | |
Doxorubicin induced heart failure model | rats, rabbits, dogs | |
Heart failure model induced by reduced ejection fraction in db/db mice fed with high-fat and high cholesterol diet | mouse |
Case sharing
Rat model of heart failure induced by pulmonary aortic constriction (PAB)
