Key Models for Drug Development in Pulmonary Arterial Hypertension

　　Pulmonary Hypertension (PH) is a serious circulatory disease defined by alterations in the structure and/or function of the pulmonary vasculature caused by a variety of heterogeneous etiologies and different pathogenic mechanisms. As the disease progresses, persistently elevated pulmonary artery pressures increase the load on the right ventricle, the pump responsible for pumping blood into the lungs. Prolonged high load makes the right ventricle progressively hypertrophied and dilated, and eventually right heart failure may develop.
　　We have established a stable model of MCT-induced pulmonary hypertension and a model of SU5416+ hypoxia-induced pulmonary hypertension, which are suitable for preclinical studies of drugs for atherosclerosis and evaluation of new drugs.
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