Key Model for Drug Development in Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial lung disease that is confined to the lungs and is prevalent in middle-aged and elderly people, with lung histology and/or high-resolution CT (HRCT) of the chest characterizing it as a generalized interstitial pneumonitis (UIP) of unknown etiology.With a mean survival of 2.8 years after diagnosis, and with a mortality rate higher than that of most tumors, IPF has been called a “tumor-like disease”. IPF has been called a “tumor-like disease”.We have established a stable model of idiopathic pulmonary fibrosis, which is suitable for preclinical studies of drugs for idiopathic pulmonary fibrosis and evaluation of new drugs.
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Disease name | Model name | Animal species |
Idiopathic pulmonary fibrosis | Single dose bleomycin (BLM) induced unilateral idiopathic pulmonary fibrosis model | rat |
Bilateral idiopathic pulmonary fibrosis model induced by single dose bleomycin (BLM) | mouse, rat | |
Unilateral idiopathic pulmonary fibrosis model induced by multiple doses of bleomycin (BLM) | rat | |
Bilateral idiopathic pulmonary fibrosis model induced by multiple doses of bleomycin (BLM) | rat |
Case sharing
BLM induced mouse lung fibrosis model
BLM induced rat unilateral lung fibrosis model
Silicon induced lung fibrosis model on rodents
