Key models for drug development in subacute and chronic renal failure
Kidney Failure (KF) is a serious kidney disease characterized by a syndrome of decreased or severely impaired kidney function resulting in metabolic disorders. Kidney Failure can be categorized into Acute Kidney Injury (AKI) and Chronic Renal Failure (CRF). Acute Kidney Injury (AKI) is a clinical syndrome resulting from rapid decline in renal function over a short period of time due to a variety of etiologic factors, and Chronic Renal Failure (CRF) is a common endpoint of a variety of renal diseases that continue to progress to advanced stages. Renal failure can lead to a variety of complications, such as cardiovascular disease and neurological disease.We have established stable multiple models of subacute/chronic renal failure, which are suitable for preclinical studies of drugs for subacute/chronic renal failure and new drug evaluation.
If you have a project need and experience more of our professional services, please contact us.
Our services
Disease name | Model name | Animal species |
Subacute/chronic renal failure | Unilateral ureteral obstruction induced renal fibrosis model | mouse, rat |
Chronic interstitial nephritis and renal fibrosis model induced by transient bilateral ureteral obstruction | rat | |
5/6 nephrectomy model | rat | |
Adenosine feed induced chronic renal failure uremia model | rat | |
Doxorubicin induced nephropathy model | rat | |
5/6 nephrectomy induced renal anemia model | rat | |
PAN induced renal micro lesion model | rat | |
Sheep serum induces a passive type of nephritis model in rats | rat |
Case sharing
5/6 nephrectomy model
Adenine induced chronic renal failure model
