Key models for drug development in liver fibrosis/cirrhosis
Liver fibrosis is a liver disease with many etiologic factors, and is most commonly seen clinically in viral hepatitis, alcoholic liver, fatty liver, and autoimmune diseases.We have established a stable liver fibrosis/cirrhosis model, which is suitable for preclinical studies and new drug evaluation of drugs for liver fibrosis/hardness.
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Model classification | Model Name | Animal species |
Liver fibrosis/cirrhosis | Carbon tetrachloride-induced liver fibrosis/cirrhosis model | Mice，rats |
Model of primary biliary cirrhosis induced by bile duct ligation | Mice，rats | |
α-Naphthyl isothiocyanate (ANIT)-induced model of primary biliary cirrhosis | Mice，rats | |
3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC)-induced model of primary biliary cirrhosis | Mice | |
Carbon tetrachloride-induced portal hypertension model of liver cirrhosis | Rats |