Porcine Blue Ear Virus
1.Porcine blue ear virus belongs to the arteritis virus family and the arteritis virus genus, and is a single stranded positive stranded RNA virus. The virus particles are spherical in shape, with a capsule and a diameter of approximately 45-60nm. This virus has a high degree of variability, with significant genetic differences between different regions and strains.2.Transmission routes: contact transmission, airborne transmission, vertical transmission
3.Porcine blue ear disease caused by porcine blue ear virus is a serious infectious disease, which poses risks to the pig farming industry in various aspects such as health, production performance, breeding costs, and industry impact.
Pig Blue Ear Disease
1.Porcine blue ear disease, also known as Porcine Reproductive and Respiratory Syndrome (PRRS), mainly infects pigs, with pregnant sows and piglets under one month of age being the most susceptible. Its dissemination methods are diverse and widely popular worldwide, with no obvious seasonality.2.Current treatment status：
Vaccination: It is a commonly used prevention and treatment method, but due to the strong variability of the virus and the low cross protection rate of vaccines, it is difficult to deal with all strains, and the immune effect is unstable.Drug therapy: The use of antibiotics can control secondary bacterial infections, but cannot completely kill the virus. It is prone to recurrence after discontinuation, and long-term use of antibiotics can lead to drug resistance and residue.
3.Current status of drug research and development:
At present, researchers are continuously searching for scientifically effective drugs and methods to treat pig blue ear disease, including new antiviral drugs, antibody drugs, cytokine drugs, etc., and trying to optimize existing drug regimens. The overall research and development stage is actively underway.KCI pig PRR model and preclinical in vivo pharmacological study
Experimental animal: Large white pig, 10wks;
Attack conditions: PRRSV NADC30-Like, Drip nose;
Experimental objective: To establish a porcine reproductive and respiratory syndrome virus infection model using nasal drip PRRSV, providing reference for subsequent antiviral and vaccine efficacy trials.Animal weight and body temperature
Experimental animals: Large white pigs, 5 weeks;
Attack conditions: PRRSV NADC30-Like, Drip nose;
Experimental objective: To use a pig PRRSV model to detect the immunogenicity and antiviral protection of the test substance in vivo, and evaluate its therapeutic effect on PRRSV.
